Whether you use Genesis or not, one often question I see is: "How do I make the top-level items non-clickable?" And they go on to say that they are linked to a category, a landing page, a blank page, a random 404 page, etc. However, it is quite simple.
First, for Genesis users, ensure that you have selected Custom Menus in Genesis > Theme Settings. Then, navigate to the custom menus option via Appearance > Menus.
Second, create the custom links menu item by filling in the URL as "#" (without the quotes) inserting a label name, then clicking Add to Menu. Then locate it anywhere on the menu and click Save Menu.
DONE!